Considerations When Storing Vaccine in
Ultra-Cold Temperatures   

Before mixing, the vaccine may be stored in an ultra-cold freezer between -90°C and -60°C (-112°F and -76°F).

Do not open the vial trays or remove vials until ready to thaw/use the vaccine.

• Once a vial is touched and removed from a tray, it begins to thaw and must be stored in the refrigerator.
• The vial must be used within 1 month (31 days).
  

Determine the number of doses/multidose vials needed for the day.

• Use vaccine vials stored in the refrigerator before removing additional vials from frozen storage.
  

Opened trays exposed to room air:

• Must be returned to ultra-cold temperatures within 3 minutes.
• Should remain at ultra-cold temperatures for 2 hours before they can be removed again.
  

Protect the vaccine from light.