Contraindications and Precautions 

Precautions to any COVID-19 vaccine include:

  • History of an immediate allergic reaction to any non-COVID-19 vaccine or injectable therapy (i.e., intramuscular, intravenous, or subcutaneous vaccines or therapies)
  • Moderate or severe acute illness

People with a history of a non-severe, immediate (onset less than 4 hours) allergic reaction after a dose of one type of COVID-19 vaccine (i.e., mRNA or Janssen) have a precaution to the same type of COVID-19 vaccine.

People with a contraindication to one type of COVID-19 vaccine have a precaution to the other type of COVID-19 vaccine (e.g., people with a contraindication to an mRNA COVID-19 vaccine have a precaution to Janssen COVID-19 vaccine and vice versa).

When applicable, consider conducting a risk assessment or referral to an allergist-immunologist to help with vaccination decision-making.


Learn more about contraindications and precautions to COVID-19 vaccines

Interim Clinical Considerations for Use of mRNA COVID-19 Vaccines Currently Authorized in the United States

ACIP General Best Practice Guidelines for Immunization



Page last reviewed: December 3, 2021