Contraindications and Precautions 

Contraindications to COVID-19 vaccination include:

  • Severe allergic reaction (e.g., anaphylaxis) after a previous dose or to a component of the COVID-19 vaccine
  • Known diagnosed allergy to a component of the COVID-19 vaccine
  • For the Janssen COVID 19 Vaccine, TTS following receipt of a previous Janssen COVID-19 Vaccine (or other COVID-19 vaccines not currently authorized in the United States that are based on adenovirus vectors)

*Additionally, people with a history of an episode of immune-mediated syndrome characterized by thrombosis and thrombocytopenia, such as spontaneous or classic HIT, should not receive Janssen COVID-19 Vaccine. These people should receive an mRNA COVID-19 vaccine.

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Learn more about contraindications and precautions to COVID-19 vaccines

Interim Clinical Considerations for Use of mRNA COVID-19 Vaccines Currently Authorized in the United States

ACIP General Best Practice Guidelines for Immunization


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Page last reviewed: March 7, 2022