Contraindications and Precautions 

Contraindications to COVID-19 vaccination include:

  • Severe allergic reaction (e.g., anaphylaxis) after a previous dose or to a component of the COVID-19 vaccine
  • Known diagnosed allergy to a component of the COVID-19 vaccine

People with a contraindication to one type of COVID-19 vaccine (i.e., mRNA COVID-19 vaccines or Janssen COVID-19 Vaccine) should not receive additional doses of that type of COVID-19 vaccine. However, people with a contraindication to mRNA COVID-19 vaccines may be able to receive Janssen COVID-19 Vaccine, and vice versa, provided certain measures are taken.


Learn more about contraindications and precautions to COVID-19 vaccines

Interim Clinical Considerations for Use of mRNA COVID-19 Vaccines Currently Authorized in the United States

ACIP General Best Practice Guidelines for Immunization



Page last reviewed: November 16, 2021