About Pfizer-BioNTech (COMIRNATY) COVID-19 Vaccine: 12 years of age and older formulation (purple cap)

Each multidose vial contains preservative-free sterile frozen liquid.

  • Each vial contains 6 doses.

Preparation: Requires mixing with 1.8 mL sterile, 0.9% sodium chloride (normal saline, preservative-free)

  • Diluent will be delivered separately from the vaccine. 

Age indications: 12 years of age and older

  • 12 through 15 years of age (available under Emergency Use Authorization
  • 16 years of age and older (approved for use for primary [2-dose] series)
  • • 12 years of age and older (available for additional primary dose [3rd dose] for moderate or severe immune compromised persons)
  • 18 years of age and older (available for booster [3rd dose] for certain high-risk populations)

Dosage: 0.3 mL

Route: IM injection

Primary series and booster schedules:

  • 2-dose primary series, separated by 21 days
    • Consider an additional dose (i.e., third dose) 28 days after the initial 2-dose primary series for moderately to severely immunocompromised people.
  • Booster dose, administered at least 6 calendar months after the last dose of the primary series for eligible people. The booster dose may be Janssen, Pfizer-BioNTech, or Moderna (0.25 mL) vaccine

The vaccine does not contain preservatives, thimerosal, antibiotics or adjuvants.

Specific information about vaccine components is in the Emergency Use Authorization of The Pfizer-BioNTech (COMIRNATY) COVID-19 Vaccine

info COMIRNATY and Pfizer-BioNTech COVID-19 Vaccine



Page last reviewed: November 16, 2021