Vaccination and Passive Antibody Therapy

Defer vaccination as a precautionary measure after receiving passive antibody products to avoid potential interference of the product with vaccine-induced immune responses:

  • Passive antibody product used for post-exposure prophylaxis: Defer COVID-19 vaccination for 30 days.
  • Passive antibody product used for COVID-19 treatment: Defer COVID-19 vaccination for 90 days.

There is no recommended minimum interval between other antibody therapies (i.e., those that are not specific to COVID-19 treatment) and mRNA COVID-19 vaccination.


Interim Clinical Considerations for Use of mRNA COVID-19 Vaccines Currently Authorized in the United States


Page last reviewed: November 16, 2021