Clinical Considerations: Prior SARS-CoV-2 Infection or Exposure 

Clinical Considerations: Prior SARS-CoV-2 Infection or Exposure

  • Persons with a history of infection: Offer vaccination regardless of history of prior symptomatic or asymptomatic SARS-CoV-2 infection.
  • Persons with known current infection: Defer vaccination until recovery from acute illness and criteria have been met to discontinue isolation.
    • Applies to persons who develop SARS-CoV-2 infection before receiving any vaccine doses and after the first dose but before receipt of the second dose
    • No minimum interval between infection and vaccination
    • Current evidence suggests that the risk of SARS-CoV-2 reinfection is low in the months after initial infection but may increase with time due to waning immunity; when vaccine supply remains limited, persons with recent documented acute SARS-CoV-2 infection may choose to temporarily delay vaccination
  • Viral testing to assess for acute SARS-CoV-2 infection or serologic testing to assess for prior infection for the purposes of vaccine decision-making is not recommended.


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Page last reviewed: September 27, 2021