Timing and Spacing

Janssen COVID-19 Vaccine is administered as a single dose.

COVID-19 vaccines are not interchangeable.

  • In limited, exceptional situations where the first dose of mRNA COVID-19 vaccine was received but the patient is unable to complete the series with the same or different mRNA vaccine (e.g., contraindication) a single dose of Janssen COVID-19 vaccine may be administered at minimum interval of 28 days from mRNA dose*
    • Considered to have received valid, single-dose Janssen vaccination, not mixed vaccination series (mRNA/viral vector)

Separate Janssen COVID-19 Vaccine by 14 days before or after the administration of other vaccines.

  • Other vaccines may be administered within a shorter period in situations where the benefits outweigh the risks (e.g., tetanus-toxoid-containing vaccination as part of wound management).

*Consider consultation with an allergist-immunologist to help determine if a patient with a contraindication to an mRNA vaccine can safely receive the Janssen COVID-19 vaccine. Healthcare providers and health departments may also request a consultation from the Clinical Immunization Safety Assessment COVIDvax project. Vaccination of these individuals should only be done in an appropriate setting under the supervision of a healthcare provider experienced in the management of severe allergic reactions.

  • People with a contraindication to mRNA COVID-19 vaccines (including due to a known PEG allergy) have a precaution to Janssen COVID-19 vaccination. People who have previously received an mRNA COVID-19 vaccine dose should wait at least 28 days to receive Janssen COVID-19 Vaccine.
  • People with a contraindication to Janssen COVID-19 Vaccine (including due to a known polysorbate allergy) have a precaution to mRNA COVID-19 vaccination.



Page last reviewed: April 20, 2021